Holger Zimmermann Selected Research

pritelivir

1/2018	Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis.
1/2017	Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action.
12/2016	Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences: A Randomized Clinical Trial.
2/2016	Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes.
1/2016	No Evidence of Pritelivir Resistance Among Herpes Simplex Virus Type 2 Isolates After 4 Weeks of Daily Therapy.
7/2014	Pharmacokinetics-pharmacodynamics of the helicase-primase inhibitor pritelivir following treatment of wild-type or pritelivir-resistant virus infection in a murine herpes simplex virus 1 infection model.
11/2013	Baseline sensitivity of HSV-1 and HSV-2 clinical isolates and defined acyclovir-resistant strains to the helicase-primase inhibitor pritelivir.

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Holger Zimmermann Research Topics

Disease

16	Infections 01/2022 - 10/2008
3	Cytomegalovirus Infections (Inclusion Disease) 01/2018 - 10/2008
1	Herpes Simplex Encephalitis (Herpes Encephalitis) 01/2018
1	Obesity 01/2017
1	Epilepsy (Aura) 01/2017
1	Glaucoma 01/2017
1	Neoplasms (Cancer) 01/2017
1	Herpes Simplex 02/2016
1	Ulcer 02/2016
1	Viremia 01/2016
1	Virus Diseases (Viral Diseases) 07/2014
1	Body Weight (Weight, Body) 07/2014

Drug/Important Bio-Agent (IBA)

9	letermovirIBA 01/2022 - 03/2010
7	pritelivirIBA 01/2018 - 11/2013
6	Antiviral Agents (Antivirals)IBA 01/2018 - 10/2008
3	Pharmaceutical PreparationsIBA 01/2017 - 03/2010
3	DNA Primase (Primase)IBA 01/2017 - 07/2014
3	Viral DNAIBA 01/2015 - 10/2008
2	terminaseIBA 01/2022 - 01/2022
2	NucleosidesIBA 12/2016 - 11/2013
1	Acyclovir (Aciclovir)FDA LinkGeneric 01/2018
1	Protein Isoforms (Isoforms)IBA 01/2017
1	Carbonic Anhydrases (Carbonic Anhydrase)IBA 01/2017
1	EnzymesIBA 01/2017
1	acetamideIBA 01/2017
1	SulfonamidesIBA 01/2017
1	Valacyclovir (Valtrex)FDA LinkGeneric 12/2016
1	Immunologic Factors (Immunomodulators)IBA 02/2016
1	Dihydrotachysterol (AT 10)IBA 07/2014
1	1- (1- (3- chloro- 4- fluorophenyl)- 5- (3- chloro- 5- fluorophenyl)- 1H- pyrazole- 3- carbonyl)imidazolidin- 4- oneIBA 11/2013
1	Reverse Transcriptase InhibitorsIBA 11/2013

Therapy/Procedure

2	Therapeutics 12/2016 - 11/2013
1	Cell Transplantation 05/2014
1	Highly Active Antiretroviral Therapy (HAART) 11/2013